22.214.171.124 Diabetes insipidus
|1st choice||Desmopressin nasal spray 10micrograms/metered spray|
Dose: See BNF
|2nd choice||Desmopressin tablets 100micrograms, 200micrograms|
|Desmopressin sublingual tablets 60 micrograms, 120 micrograms, 240 micrograms||Dose:|
- A single dose of desmopressin is also used as part of a test following fluid deprivation in the differential diagnosis of thirst and polyuria.
- For nephrogenic diabetes insipidus, the usual treatment is a thiazide diuretic. Caution if due to lithium – refer to endocrinologist.
- Desmopressin injection (4 micrograms/mL) may be indicated in unconscious patients (dose 1-4 micrograms daily by subcutaneous, intramuscular or intravenous injection).
- Measurement of plasma sodium should be undertaken to guard against excessive water intake which would be reflected by a low plasma sodium. The frequency of monitoring should be individualised and more frequent monitoring will be required during the stabilisation phase.