2.2.2 Loop diuretics

ChoiceDrugDosage
1st choiceFurosemide tablets 20mg, 40mg; injection 10mg/ml

Dose:
Orally, initially 40mg in the morning then adjusted according to response.

By slow intravenous injection, initially 20-40mg. A rate of 4mg per minute should not be exceeded, however a single dose of up to 80mg may be administered more rapidly.

For repeated doses - give doses above 50mg by slow intravenous infusion only. IV infusion rates should not exceed 4mg per minute

See BNF for further details

2nd choiceBumetanide tablets 1mg, 5mg;

Dose:
Orally, 1mg in the morning, then adjusted according to response

Elderly, 500micrograms daily may be sufficient In severe oedema, 5mg daily increased by 5mg every 12-24 hours according to response (only under secondary care guidance)

Prescribing Notes

  • Furosemide produces a dose-dependent diuresis within 1 hour if given orally or 30 minutes if given intravenously; duration of action, 6 hours and thus can be given twice daily without interfering with sleep (second dose preferably no later than 4pm).
  • Both thiazide and loop diuretics can cause sodium and potassium depletion, glucose intolerance and gout. The hypokalaemia which may occur following the use of thiazide or loop diuretics can be dangerous in patients with severe ischaemic heart disease or when cardiac glycosides are used. Combination with a potassium-sparing diuretic, ACE inhibitor/ARB should be considered in these patients. Oral potassium supplementations are relatively inefficient.
  • 1mg bumetanide is equivalent to 40mg furosemide.

Cautions

  • Elderly patients are particularly susceptible to the side-effects of diuretics including increased risk of postural hypotension, collapse and falls. Confusion, dehydration, urinary incontinence and hyponatraemia may be particular problems.
  • Diuretics should not be used on a long term basis to treat simple gravitational oedema. This will usually respond to increased ambulation, raising the legs and support stockings.