4.10.4.3 Interventions for the reduction of alcohol consumption

NICE CG 115 recommends that the first line treatment option in mild alcohol dependence is a psychological intervention.
Nalmefene^▼ is recommended by NICE as an option for reducing alcohol consumption. It is important that prescribers are aware of the prescribing requirements outlined by NICE and that nalmefene^▼ is only prescribed in line with these to avoid inappropriate prescribing. Refer to NICE TA325.

- Nalmefene^▼ is an option for people with alcohol dependence who have a high drinking risk level (defined as alcohol consumption of more than 60g [or 7.5 units] per day for men and more than 40g [5 units] per day for women, according to the World Health Organization’s drinking risk levels) without physical withdrawal symptoms and who do not require immediate detoxification.
- Nalmefene^▼ should:
  - only be prescribed in conjunction with continuous psychosocial support focused on treatment adherence and reducing alcohol consumption and
  - be initiated only in patients who continue to have a high drinking risk level two weeks after initial assessment