| Choice | Drug | Dosage |
|---|---|---|
1st choice For information Specialist initiation only | Modafinil tablets 100mg | Dose: Initially 200mg daily either in 2 divided doses morning and at noon or as a single dose in the morning, dose adjusted according to response to 200-400mg daily in 2 divided doses or as a single dose; elderly initiate at 100mg daily |
Prescribing Notes
- Modafinil is an amber list drug and should be initiated by a specialist
- Supervision should remain the responsibility of hospital staff for the first three months or until objective evidence of effectiveness has been provided
- Dependence with long-term use of modafinil cannot be excluded
- Dexamfetamine sulphate or methylphenidate hydrochloride may be prescribed by specialists when modafinil is ineffective
Cautions
- Modafinil potentially increases the risk of congenital malformations when used in pregnancy. Modafinil should not be used during pregnancy and women of childbearing potential must use effective contraception during treatment and for 2 months after stopping modafinil. See MHRA