4.4.1 Narcolepsy


1st choice

For information

Specialist initiation only

Modafinil tablets 100mg

Initially 200mg daily either in 2 divided doses morning and at noon or as a single dose in the morning, dose adjusted according to response to 200-400mg daily in 2 divided doses or as a single dose;
elderly initiate at 100mg daily

Prescribing Notes

  • Modafinil is an amber list drug and should be initiated by a specialist – see IPNSM red/amber lists.
  • Supervision should remain the responsibility of hospital staff for the first three months or until objective evidence of effectiveness has been provided.
  • Dependence with long-term use of modafinil cannot be excluded.
  • Dexamfetamine sulphate or methylphenidate hydrochloride may be prescribed by specialists when modafinil is ineffective.