6.1.2.2 Sulfonlyureas

ChoiceDrugDosage
Formulary choiceGliclazide tablets 80mgDose: Initially 40-80mg daily before main meal, max 320mg daily; doses above 160mg daily should be divided Mild to moderate renal impairment : use the same dosing regimen as in normal renal function with careful patient monitoring Severe renal impairment: avoid (risk of hypoglycaemia)

Prescribing Notes

  • Gliclazide modified release tablets should be reserved for patients with demonstrable compliance problems.
  • If gliclazide MR is necessary, Bilxona® MR is the recommended cost-effective choice.
  • Patients should be informed that sulfonylureas can cause hypoglycaemia. The risk of hypoglycaemia increases with age.
  • Driving requirements and advice for monitoring of blood glucose in people with type 2 diabetes differ depending on medication and license group. Information may be accessed on the GOV.UK website.