There are currently very limited, intermittent supplies of all glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Supplies are not expected to stabilise to meet full market demand until at least December 2024. Please refer to GLP1 MSN for further information.
Prescribing Notes
- Prescribe as per NICE NG28 recommendations. See also NICE visual summary for blood glucose lowering therapy in adults with type 2 diabetes.
- Stop DPP-4 inhibitor if initiating GLP-1 receptor agonist (the combination is unlikely to provide synergistic effects beyond monotherapy with either agent).
- The formulary covers the use of GLP-1 receptor agonists in type 2 diabetes only. GLP-1 receptor agonists should not be prescribed for managing overweight and obesity until a specialist weight management service (tier 3) has been established. See correspondence for further details.
- To prevent waste, please avoid prescribing large quantities. GLP-1 receptor agonists require refrigeration and are expensive. One month’s supply should be adequate for most patients – refer to GLP-1 agonists supplement for further details on appropriate quantities.
- Stopping rules with GLP-1 receptor agonists: NICE state only continue GLP‑1 receptor agonist therapy if the person with type 2 diabetes has had a beneficial metabolic response (a reduction of at least 11 mmol/mol [1.0%] in HbA1c and a weight loss of at least 3% of initial body weight in 6 months).
- Gastric emptying may be delayed, therefore the rate and extent of absorption of other oral drugs administered at the same time may be affected.
- Doses of concomitant sulfonylurea may need to be reduced when a GLP-1 receptor agonist is started.
- Upper gastrointestinal side effects such as nausea are common with GLP-1 receptor agonist therapy.
- There are rare reports of acute pancreatitis in patients using these drugs. GLP-1 receptor agonists should be avoided in patients considered to be at high risk of pancreatitis. Patients and their carers should be told how to recognise signs and symptoms of pancreatitis.
- Thyroid adverse events (including increased blood calcitonin, goitre and thyroid neoplasm) have been rarely reported in clinical trials with liraglutide, particularly in patients with pre-existing thyroid disease.
Cautions
- Diabetic ketoacidosis has been reported in patients with type 2 diabetes on a combination of a GLP-1 receptor agonist and insulin who had doses of concomitant insulin rapidly reduced or discontinued. See MHRA for further details.