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    2.6.3 Ranolazine

    ChoiceDrugDosage

    Reserve

    [For information only, not a NI Formulary Choice]

    Ranolazine (Ranexa®) tablets m/r 375mg, 500mg, 750mg

    Dose: Initially 375mg twice daily, increased if necessary after 2-4 weeks to 500mg twice daily Please note, in practice, 375mg twice daily is often used as a maintenance dose.

    Higher doses may lead to QT prolongation (exercise caution with doses greater than 500mg twice daily)

    Prescribing Notes

    • Ranolazine may be useful for patients intolerant of other anti-anginal treatments, especially those with low BP and/or low heart rate.

    Caution

    • Caution in patients with borderline renal function (avoid if eGFR less than 30mL/minute/1.73m2)
    • Ranolazine is largely metabolised by the CYP3A4 system and there is a potential for serious drug interactions (see BNF)