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7.1.1 Primary dysmenorrhoea

ChoiceDrug
1st choiceIbuprofen tablets 200mg, 400mg
Or
Naproxen 250mg, 500mg
(Plain tablets, not e/c)
2nd choice

Paracetamol tablets 500mg

Prescribing Notes

  • Prescribe as per NICE CKS: Dysmenorrhoea.
  • For optimal effect, regular analgesics should be initiated just before anticipated onset of menstruation.
  • If the woman does not wish to conceive, hormonal contraceptives may be considered as alternative first line treatment (see section 7.3.1)since they may prevent the pain of dysmenorrhea.
  • Refer if symptoms are severe and not responding to initial treatment within 3-6 months, or where symptoms are deteriorating with time, or if there is doubt about the diagnosis.

Cautions

  • Mefenamic acid is not listed as a formulary choice. There are concerns that mefenamic acid is more likely to cause seizures in overdose than other NSAIDs; mefenamic acid has a narrow therapeutic window which increases the risk of accidental overdose.