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7.1.6 Premenstrual syndrome

ChoiceDrug
All women with PMSOffer lifestyle advice and treat predominant symptoms
Moderate PMS symptoms New generation COC
e.g. Gedarel® 30/150 (desogestrel 150 micrograms, ethinylestradiol 30 micrograms)
Severe PMS symptomsFluoxetine 20mg capsules

Prescribing Notes

  • For more information refer to CKS guidance: Premenstrual syndrome.
  • The COC can be used cyclically or continuously for PMS although current data suggest continuous rather than cyclical use.
  • Fluoxetine can be considered for women with severe PMS (off-label use), to be taken continuously or just during the luteal phase.

Cautions